Pharmacognostic analysis and antidiabetic potential of selected marketed polyherbal formulations

Résumé

Background: Diabetes Mellitus is increasing day by day due to comfort in daily life. So, there is an increase demand of the polyherbal formulations worldwide for the treatment of Diabetes Mellitus. So quality assurance of these products of great concern in developing countries like Pakistan. Methods: The PHFs were collected from the local market. Their quality control parameters, pharmacognostic evaluation, in vivo antidiabetic assay and oral glucose tolerance were evaluated and compared with standard drug metformin. Objectives: The objective of this study was phytochemical evaluation and Comparative evaluation of the antidiabetic activity of PHFs. Results: In the in vivo antidiabetic assay, the PHFs showed the time and dose dependent lowering in the blood glucose level of the alloxan (150mg/kg) rats at days 1, 4, 8, 12, 16 compared to the diabetic control group (p < 0.001). zubex, (PHF) showed maximum hypoglycemic effect at both doses (250,500 mg/kg). The ziabeen (PHF) cause the lowering in the blood glucose level but not in the significant way. Dawa-e-ajeeb ziabetees showed efficacy at the dose (500 mg/kg) not showed significant efficacy at dose (250 mg/kg). PHFs at 250,500 mg/Kg improved oral glucose tolerance overload in rats compared to hyperglycemic control group (p < 0.001), like metformin. Conclusion: It was concluded that tested PHFs were of standard quality control, while zubex have maximum antidiabetic activity compared to the standard drug.