A Review of Innovative Nanoparticle Based Approaches for the Treatment of Liver Cancer

Abstract

Abstract:

Background: Hepatocellular carcinoma (HCC) is the most prevalent type of liver cancer with poor prognosis. Various drugs have been used to inhibit cancer cell proliferation, angiogenesis, and induce tumor cell apoptosis. However, drugs resistance, poor solubility, reduced bioavailability, restricted their clinical applications. Therefore, there is a need to develop novel therapeutic approaches based on nanoparticles (NPs) to enhance targeted drug delivery and improve therapeutic efficacy of HCC. Method: In this review, we retrieved already published data on nanoparticles-based vaccines, from PubMed, Google Scholar, Cochrane Library, and Science Direct. Results: These results indicate significant role of NPs based anti-cancer vaccines for the treatment of HCC or liver cancer. NPs based cancer vaccines compared to conventional liver cancer treatment showed lesser side effects, increased safety, minimum risk to normal body cells, reduced tumor growth, and enhanced delivery of anti-cancer drugs using NPs. Conclusion: Based on the literature, the study concluded that NPs based anti-cancer liver vaccines can provide better alternative to traditional liver cancer treatments like liver resection, liver transplantation, chemotherapy, and radiotherapy.