The Liver Associated Diseases in patient with Diabetes Mellitus from Islamabad Region

Abstract

Background: Type 2 Diabetes is a risk factor for progression of many liver associated diseases such as NAFLD, Hepatitis B and C, HCC, Liver Cirrhosis, Acute kidney diseases, glomerunephrities and obesity. We examined prevalence of advanced liver disease in people of type 2 Diabetes and analyzed the changes in liver, renal and lipid profile as a screening tool. Methods: A Hospital based cross-sectional study was performed and data was collected from hematology, chemistry and clinical Pathology department of Umar diabetic foundation and The diabetic center. In this descriptive study, LFTs, RFTs, Lipid profile and Micro albumin were measured in the diabetic patients.Results: A total of 60 patients from different regions of Islamabad were tested during this time. Amongst which 51 patients were Diabetic, 4 were prediabetic and 5 patients were completely normal with no associated disease. Out of those 51 diabetic patients, 26 were male and 25 were female. Furthermore, 30 out of 51 patients were diagnosed with Non-Alcoholic Fatty liver Disease, which was the highest percentage amongst other associated diseases of our report. Other than this, these diabetic patients also presented with high ratio of acute kidney infections and Obesity.Conclusion: Type 2 diabetes is associated with a large number of liver disorders including fatty liver, cirrhosis, hepatocellular carcinoma, and acute liver failure. In addition, there is an unexplained association with HCV. Moreover, blood parameters such as liver enzymes, RFTs and sometimes lipid profile is also disturbed. Comprehensive strategies need to be developed to incorporate screening, prevention and treatment of type 2 diabetes at a community level.

KEYWORDS

Type 2 diabetes, HCC (Hepatocellular carcinoma), NAFLD (Nonalcoholic fatty Liver disease), Obesity.